GinkgolideA, 7-hydroxy-, (7β)-
Ginkgolide J
CAS: 107438-79-9
Molecular Formula: C20H24O10
GinkgolideA, 7-hydroxy-, (7β)- - Names and Identifiers
| Name | Ginkgolide J |
| Synonyms | BN 52024 J Ginkgoli Ginkgolide J GINKGOLIDE J 7beta-hydroxyginkgolide a GinkgolideA, 7-hydroxy-, (7β)- |
| CAS | 107438-79-9 |
| InChI | InChI=1/C20H24O10/c1-6-12(23)27-7-5-17-11-8(21)9(16(2,3)4)18(17)10(22)13(24)29-15(18)30-20(17,14(25)28-11)19(6,7)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10?,11-,15+,17?,18?,19-,20+/m1/s1 |
GinkgolideA, 7-hydroxy-, (7β)- - Physico-chemical Properties
| Molecular Formula | C20H24O10 |
| Molar Mass | 424.4 |
| Density | 1?+-.0.1 g/cm3(Predicted) |
| Melting Point | >282oC (dec.) |
| Boling Point | 760.4±60.0 °C(Predicted) |
| Specific Rotation(α) | -11.8° (c=1，Ethanol) |
| Flash Point | 273.6°C |
| Solubility | Insoluble in water |
| Vapor Presure | 1.09E-26mmHg at 25°C |
| Appearance | White crystal |
| Color | White |
| pKa | 11.28±0.70(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Refractive Index | 1.65 |
| MDL | MFCD03093737 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Ginkgo biloba. |
| In vivo study | Ginkgolide J (100 μM) treatment reduces the apoptotic damage induced by serum deprivation (24h) or treatment with Staurosporine (200 nM, 24h) in cultured chick embryonic neurons. |
GinkgolideA, 7-hydroxy-, (7β)- - Risk and Safety
| WGK Germany | 3 |
GinkgolideA, 7-hydroxy-, (7β)- - Reference
| Reference Show more | 1. [IF=3.935] Xingliang Niu et al."Hydrogen/deuterium exchange, a unique and effective method for MS fragmentation behavior elucidation of ginkgolides and its application to systematic research in Ginkgo biloba."J Pharmaceut Biomed. 2017 Feb;134:181 2. [IF=4.098] Yi Zhong et al."An online, non-destructive method for simultaneously detecting chemical, biological, and physical properties of herbal injections using hyperspectral imaging with artificial intelligence."Spectrochim Acta A. 2022 Jan;264:120250 3. [IF=3.935] Yi Zhong et al."A strategy for identifying effective and risk compounds of botanical drugs with LC-QTOF-MS and network analysis: A case study of Ginkgo biloba preparation."J Pharmaceut Biomed. 2021 Jan;193:113759 4. [IF=3.935] Yongyi Li et al."Integrated molecular networking strategy enhance the accuracy and visualization of components identification: A case study of Ginkgo biloba leaf extract."J Pharmaceut Biomed. 2022 Feb;209:114523 |
GinkgolideA, 7-hydroxy-, (7β)- - Reference Information
| Biological activity | Ginkgolide J is the main component of the non-flavonoid part of Ginkgo biloba leaves, and the IC50 range is 12-54 µM, Has the ability to protect and resist neuronal apoptosis. |
| in vivo study | Ginkgolide J (100 μM) treatment reduces the apoptotic damage induced by series deprivation (24h) or treatment with Staurosporine (200 nM, 24h) in cultured chick embryonic neurons. |
| chemical properties | white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ginkgo biloba leaves. |
| use | ginkgolide J has the effect of reducing, alleviating and improving myocardial ischemia. used for content determination/identification/pharmacological experiment, etc. |
Last Update：2024-04-09 01:59:58
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QQ: 2853786052
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